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Postdoctoral Scholar, Division of Allergy & Infectious Diseases (Syphilis pathogenesis and immunology)
The Giacani Lab, under the Department of Medicine, University of Washington, is focused on identifying vaccine candidates and immune mechanisms of protection against Treponema pallidum, the causative agent of syphilis. We perform detailed studies using specimens derived from the rabbit model of infection and human samples. A major focus of the lab is also the study of syphilis pathogenesis, which can be now pursued more actively thanks to recent advancements in the field that allow to propagate this pathogen in vitro and genetically engineer it. Projects include:Creating knock-out mutants or mutants expressing GFP-fusion proteins to study how ablation of putative virulence factors affect infectivity, and to study pathogen dissemination.Testing vaccine cand
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